Antidepressants

  • Antidepressants are known to produce a multitude of side effects.
  • However, since 2019 the European Medicines Agency has recognised that antidepressants can produce a syndrome called PSSD.
  • Some of the symptoms of this syndrome include sexual and emotional symptoms.
  • Sexual dysfunction following SSRIs is an iatrogenic disorder in which people who have been given selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitor (SSRI) drugs experience persistent changes in sexual, cognitive and emotional function for a prolonged period after stopping the drug.
  • Although SSRIs are the most common cause, cases have also been reported following the use of serotonin and norepinephrine reuptake inhibitors (SNRIs), SRI tricyclic antidepressants, SRI antihistamines, tetracycline antibiotics such as doxycycline, and painkillers such as tramadol.
  • The medical term, ‘PSSD’, does not accurately highlight the debilitating cognitive and emotional impairment that many people with this condition also suffer.
  • In addition, there are many self-reports of the condition arising after the use of tricyclic antidepressants, atypical antidepressants and antipsychotics.
ISRS IRSN
Citalopram (Celexa) Venlafaxina (Effexor)
Escitalopram (Lexapro) Des-venlafaxina (Pristiq)
Fluoxetina (Prozac) Duloxetina (Cymbalta)
Fluvoxamina (Luvox) Atomoxetina (Strattera)
Paroxetina (Paxil) Levo-milnaciprán (Fetzima)
Sertralina (Zoloft) Vortioxetina (Trintellix)
Antidepresivos atípicos Antipsicóticos
Bupropión (Wellbutrin SR, Wellbutrin XL, otros) Risperidona (Risperdal)
Mirtazapina (Remeron) Quetiapina (Seroquel)
nefazodona Olanzapina (Zyprexa)
trazodona Ziprasidona (Zeldox)
Vilazodona (Viibryd) Paliperidona (Invega)
Aripiprazol (Abilify) Clozapina (Clozaril)

SEXUAL and NON-SEXUAL SYMPTOMS CAN INCLUDE

Síntomas sexuales Otros síntomas
Disfunción eréctil Incapacidad para sentir ciertas emociones
(por ejemplo, miedo, euforia, amor)
Pérdida de libido entumecimiento de la piel
Genitales entumecidos Deterioro cognitivo (memoria, pensamiento)
orgasmos sin placer Otras alteraciones sensoriales (olfato, gusto, visión)
Pérdida de erecciones nocturnas. Despersonalización
sequedad vaginal Cambios en el ciclo menstrual
Disminución del volumen y/o calidad seminal Anhedonia
Incapacidad para el orgasmo (anorgasmia)
Disminución del tamaño del pene o testicular
Reducción de la capacidad para excitarse sexualmente.