Finasteride

It is a medication indicated to stop androgenic alopecia. Initially its purpose was to treat benign prostatic hyperplasia, but it was detected that one of its effects was to improve hair quality and stimulate hair production. Hence it began to be used to treat alopecia.

Post-Finasteride Syndrome (PFS) describes persistent sexual, neurological, and physical adverse reactions in patients who have taken finasteride, a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (under the name Propecia or generics) or prostate enlargement (Proscar or generics). Unfortunately, SPF is a condition that has no known cure and few, if any, effective treatments. As increasing numbers of men report their persistent side effects to health and regulatory agencies around the world, the medical and scientific communities are only beginning to realize the magnitude of the problem.

SEXUAL AND NON-SEXUAL SYMPTOMS MAY INCLUDE

Sexual

Libido
  • Decrease or total loss of sexual desire
 
Erection
  • Erectile dysfunction, impotence
  • Loss of morning and spontaneous erections
 
Orgasm Disorders
  • Sexual Anhedonia, loss of pleasurable orgasm
 
Ejaculatory Disorders
  • Reduction in semen volume and ejaculation force
 
Penis
  • Penile shrinkage and insensitivity
  • Peyronie’s disease
 
Testicles
  • Scrotal shrinkage and genital numbness

Physical

Ginecomastia
  • Breast development and enlargement as a woman
 
Fatigue
  • Chronic fatigue, reluctance
 
Muscles
  • Myalgia, including muscle pain
  • Myopathy, encompassing muscle weakness, cramps, stiffness and tetany (tics)
  • Myasthenia, including muscle weakness
  • Rhabdomyolysis, including muscle atrophy
  • Elevation of creatine kinase
 
Skin
  • Decreased fat and sebum production
  • Chronically dry and thin skin
  • Melasma (brownish spots and patches that typically affect sun-exposed areas of the face)
 
Tissue
  • Lipoatrophy (localized loss of adipose tissue)
 
Ear
  • Tinnitus (ringing in the ears)
 
Metabolism
  • Mellitus diabetes
  • Increased fat deposition, obesity and high body mass index
  • Decreased body temperature
  • Reduction in HDL cholesterol, increase in glucose and triglycerides during fasting
  • Elevated rheumatoid factors

Mental and Neurological

Memory
  • Severe memory/memory dysfunction
 
Cognition
  • Slower reasoning processes
  • Impaired problem solving, decreased understanding
  • Brain fog
 
Psychological
  • Depression
  • Anxiety
  • Suicidal ideation
 
Emotional
  • Affective flattening and anhedonia
 
Sleep
  • Insomnia
  • Obstructive sleep apnea
 
Self harm
  • Suicide attempt
  • Suicide